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Index > Protein center > Fn1(Gene name) > Mouse
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  • Fn1 (Gene name),
  • Fibronectin (Protein name ),  FINC_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Fn1;
    Protein name:
    Fibronectin(FN);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, LGALS3BP and COL13A1 and COMP (By similarity). Interacts with TNR; interaction mediates inhibition of cell adhesion and neurite outgrowth. Interacts with FBLN7. Interacts with FST3.
    Function:
    Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    2477
    Sequence:
    50:
    MLRGPGPGRL | LLLAVLCLGT | SVRCTEAGKS | KRQAQQIVQP | QSPVAVSQSK | 
    100:
    PGCFDNGKHY | QINQQWERTY | LGNALVCTCY | GGSRGFNCES | KPEPEETCFD | 
    150:
    KYTGNTYKVG | DTYERPKDSM | IWDCTCIGAG | RGRISCTIAN | RCHEGGQSYK | 
    200:
    IGDKWRRPHE | TGGYMLECLC | LGNGKGEWTC | KPIAEKCFDH | AAGTSYVVGE | 
    250:
    TWEKPYQGWM | MVDCTCLGEG | NGRITCTSRN | RCNDQDTRTS | YRIGDTWSKK | 
    300:
    DNRGNLLQCV | CTGNGRGEWK | CERHALQSAS | AGSGSFTDVR | TAIYQPQTHP | 
    350:
    QPAPYGHCVT | DSGVVYSVGM | QWLKSQGNKQ | MLCTCLGNGV | SCQETAVTQT | 
    400:
    YGGNSNGEPC | VLPFTYNGRT | FYSCTTEGRQ | DGHLWCSTTS | NYEQDQKYSF | 
    450:
    CTDHAVLVQT | RGGNSNGALC | HFPFLYNNRN | YTDCTSEGRR | DNMKWCGTTQ | 
    500:
    NYDADQKFGF | CPMAAHEEIC | TTNEGVMYRI | GDQWDKQHDL | GHMMRCTCVG | 
    550:
    NGRGEWACIP | YSQLRDQCIV | DDITYNVNDT | FHKRHEEGHM | LNCTCFGQGR | 
    600:
    GRWKCDPIDQ | CQDSETRTFY | QIGDSWEKFV | HGVRYQCYCY | GRGIGEWHCQ | 
    650:
    PLQTYPGTTG | PVQVIITETP | SQPNSHPIQW | NAPEPSHITK | YILRWRPKTS | 
    700:
    TGRWKEATIP | GHLNSYTIKG | LTPGVIYEGQ | LISIQQYGHR | EVTRFDFTTS | 
    750:
    ASTPVTSNTV | TGETAPYSPV | VATSESVTEI | TASSFVVSWV | SASDTVSGFR | 
    800:
    VEYELSEEGD | EPQYLDLPST | ATSVNIPDLL | PGRKYIVNVY | QISEEGKQSL | 
    850:
    ILSTSQTTAP | DAPPDPTVDQ | VDDTSIVVRW | SRPQAPITGY | RIVYSPSVEG | 
    900:
    SSTELNLPET | ANSVTLSDLQ | PGVQYNITIY | AVEENQESTP | VFIQQETTGT | 
    950:
    PRSDNVPPPT | DLQFVELTDV | KVTIMWTPPD | SVVSGYRVEV | LPVSLPGEHG | 
    1000:
    QRLPVNRNTF | AEITGLSPGV | TYLFKVFAVH | QGRESNPLTA | QQTTKLDAPT | 
    1050:
    NLQFVNETDR | TVLVTWTPPR | ARIAGYRLTA | GLTRGGQPKQ | YNVGPLASKY | 
    1100:
    PLRNLQPGSE | YTATLVAVKG | NQQSPKATGV | FTTLQPLRSI | PPYNTEVTET | 
    1150:
    TIVITWTPAP | RIGFKLGVRP | SQGGEAPREV | TSDSGSIVVS | GLTPGVEYTY | 
    1200:
    TIQVLRDGQE | RDAPIVNRVV | TPLSPPTNLH | LEANPDTGVL | TVSWERSTTP | 
    1250:
    DITGYRITTT | PTNGQQGTSL | EEVVHADQSS | CTFENLNPGL | EYNVSVYTVK | 
    1300:
    DDKESAPISD | TVVPEVPQLT | DLSFVDITDS | SIGLRWTPLN | SSTIIGYRIT | 
    1350:
    VVAAGEGIPI | FEDFVDSSVG | YYTVTGLEPG | IDYDISVITL | INGGESAPTT | 
    1400:
    LTQQTAVPPP | TDLRFTNIGP | DTMRVTWAPP | PSIELTNLLV | RYSPVKNEED | 
    1450:
    VAELSISPSD | NAVVLTNLLP | GTEYLVSVSS | VYEQHESIPL | RGRQKTGLDS | 
    1500:
    PTGFDSSDIT | ANSFTVHWVA | PRAPITGYII | RHHAEHSVGR | PRQDRVPPSR | 
    1550:
    NSITLTNLNP | GTEYVVSIIA | VNGREESPPL | IGQQATVSDI | PRDLEVIAST | 
    1600:
    PTSLLISWEP | PAVSVRYYRI | TYGETGGNSP | VQEFTVPGSK | STATINNIKP | 
    1650:
    GADYTITLYA | VTGRGDSPAS | SKPVSINYKT | EIDKPSQMQV | TDVQDNSISV | 
    1700:
    RWLPSTSPVT | GYRVTTTPKN | GLGPSKTKTA | SPDQTEMTIE | GLQPTVEYVV | 
    1750:
    SVYAQNRNGE | SQPLVQTAVT | NIDRPKGLAF | TDVDVDSIKI | AWESPQGQVS | 
    1800:
    RYRVTYSSPE | DGIRELFPAP | DGEDDTAELQ | GLRPGSEYTV | SVVALHDDME | 
    1850:
    SQPLIGIQST | AIPAPTNLKL | SQVTPTSFTA | QWIAPSVQLT | GYRVRVNPKE | 
    1900:
    KTGPMKEINL | SPDSSSVIVS | GLMVATKYEV | SVYALKDTLT | SRPAQGVITT | 
    1950:
    LENVSPPRRA | RVTDATETTI | TISWRTKTET | ITGFQVDAIP | ANGQTPVQRS | 
    2000:
    ISPDVRSYTI | TGLQPGTDYK | IHLYTLNDNA | RSSPVIIDAS | TAIDAPSNLR | 
    2050:
    FLTTTPNSLL | VSWQAPRARI | TGYIIKYEKP | GSPPREVVPR | PRPGVTEATI | 
    2100:
    TGLEPGTEYT | IYVIALKNNQ | KSEPLIGRKK | TDELPQLVTL | PHPNLHGPEI | 
    2150:
    LDVPSTVQKT | PFITNPGYDT | ENGIQLPGTT | HQQPSVGQQM | IFEEHGFRRT | 
    2200:
    TPPTAATPVR | LRPRPYLPNV | DEEVQIGHVP | RGDVDYHLYP | HVPGLNPNAS | 
    2250:
    TGQEALSQTT | ISWTPFQESS | EYIISCQPVG | TDEEPLQFQV | PGTSTSATLT | 
    2300:
    GLTRGVTYNI | IVEALQNQRR | HKVREEVVTV | GNAVSEGLNQ | PTDDSCFDPY | 
    2350:
    TVSHYAIGEE | WERLSDAGFK | LTCQCLGFGS | GHFRCDSSKW | CHDNGVNYKI | 
    2400:
    GEKWDRQGEN | GQRMSCTCLG | NGKGEFKCDP | HEATCYDDGK | TYHVGEQWQK | 
    2450:
    EYLGAICSCT | CFGGQRGWRC | DNCRRPGAAE | PSPDGTTGHN | YNQYTQRYNQ | 
    2477:
    RTNTNVNCPI | ECFMPLDVQA | DRDDSRE
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    SMR:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse FN
    Cat.:
    E0037h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse FN
    Cat.:
    E0037m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse FN
    Cat.:
    E0037r
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse FN
    Cat.:
    E0037d
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse FN
    Cat.:
    E0037b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse FN
    Cat.:
    E0037c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse FN
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse FN
    Cat.:
    U0037c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse FN
    Cat.:
    U0037b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse FN
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse FN
    Cat.:
    U0037d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse FN
    Cat.:
    U0037r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse FN
    Cat.:
    U0037m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse FN
    Cat.:
    U0037h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Mouse FN
    Cat.:
    P0037Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse FN
    Polyclonal Antibody for Mouse FN
    Polyclonal Antibody for Mouse FN
    Cat.:
    P0037Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse FN
    Cat.:
    P0037Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse FN
    Polyclonal Antibody for Mouse FN
    Monoclonal Antibody for Mouse FN
    Monoclonal Antibody for Mouse FN
    Monoclonal Antibody for Mouse FN
    Monoclonal Antibody for Mouse FN
    Monoclonal Antibody for Mouse FN
    Monoclonal Antibody for Mouse FN
    Monoclonal Antibody for Mouse FN
    Protein for Mouse FN
    Protein for Mouse FN
    Protein for Mouse FN
    Protein for Mouse FN
    Protein for Mouse FN
    Protein for Mouse FN
    Protein for Mouse FN

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    2. 2.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-920
      strain: FVB/N-3.
      tissue: Mammary tumor.
    4. 4.
      "Sequence of the mouse fibronectin-encoding gene promoter region."
      Polly P. , Nicholson R.C.
      Gene137:353-354(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28
      tissue: Liver.
    5. 5.
      "Regulation of mesenchymal extracellular matrix protein synthesis by transforming growth factor-beta and glucocorticoids in tumor stroma."
      Talts J.F. , Weller A. , Timpl R. , Ekblom M. , Ekblom P.
      J. Cell Sci.108:2153-2162(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 562-834
      strain: NMRI.
    6. 6.
      Gorski G. , Aros M. , Norton P.
      Submitted (1995-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 899-2376
    7. 7.
      "Induction of fibronectin gene transcription and mRNA is a primary response to growth-factor stimulation of AKR-2B cells."
      Blatti S.P. , Foster D.N. , Ranganthan G. , Moses H.L. , Getz M.J.
      Proc. Natl. Acad. Sci. U.S.A.85:1119-1123(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2375-2477
    8. 8.
      "Coordinate induction of fibronectin, fibronectin receptor, tropomyosin, and actin genes in serum-stimulated fibroblasts."
      Ryseck R.P. , MacDonald-Bravo H. , Zerial M. , Bravo R.
      Exp. Cell Res.180:537-545(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2375-2477
    9. 9.
      "Fibronectin gene expression in proliferating, quiescent, and SV40-infected mouse kidney cells."
      Khandjian E.W. , Salomon C. , Leonard N. , Tremblay S. , Turler H.
      Exp. Cell Res.202:464-470(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2375-2477
      tissue: Kidney.
    10. 10.
      "Covalent cross-linking of fibronectin to fibrin is required for maximal cell adhesion to a fibronectin-fibrin matrix."
      Corbett S.A. , Lee L. , Wilson C.L. , Schwarzbauer J.E.
      J. Biol. Chem.272:24999-25005(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TRANSGLUTAMINATION AT GLN-35; GLN-36 AND GLN-48;MUTAGENESIS OF GLN-35; GLN-36 AND GLN-48
    11. 11.
      "Glucocorticoids down-regulate the extracellular matrix proteins fibronectin, fibulin-1 and fibulin-2 in bone marrow stroma."
      Gu Y.-C. , Talts J.F. , Gullberg D. , Timpl R. , Ekblom M.
      Eur. J. Haematol.67:176-184(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOWN-REGULATION BY GLUCOCORTICOIDS
    12. 12.
      "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
      Ghesquiere B. , Van Damme J. , Martens L. , Vandekerckhove J. , Gevaert K.
      J. Proteome Res.5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1006
      strain: C57BL/6.
      tissue: Plasma.
    13. 13.
      "TM14 is a new member of the fibulin family (fibulin-7) that interacts with extracellular matrix molecules and is active for cell binding."
      de Vega S. , Iwamoto T. , Nakamura T. , Hozumi K. , McKnight D.A. , Fisher L.W. , Fukumoto S. , Yamada Y.
      J. Biol. Chem.282:30878-30888(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FBLN7
    14. 14.
      "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
      Bernhard O.K. , Kapp E.A. , Simpson R.J.
      J. Proteome Res.6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-528
      strain: C57BL/6.
      tissue: Plasma.
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2475;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    16. 16.
      "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H. , Ye M. , Dong J. , Han G. , Jiang X. , Wu R. , Zou H.
      J. Proteome Res.7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2475;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    17. 17.
      "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L. , Raginski K. , Tarasova Y. , Tchernyshyov I. , Bausch-Fluck D. , Elliott S.T. , Boheler K.R. , Van Eyk J.E. , Wollscheid B.
      Mol. Cell. Proteomics8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-528; ASN-1001; ASN-1006; ASN-1290 AND ASN-2198
      tissue: Myoblast.
    18. 18.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2475;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    19. 19.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1006 AND ASN-1290
    20. 20.
      "Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition."
      Brunner M. , Millon-Fremillon A. , Chevalier G. , Nakchbandi I.A. , Mosher D. , Block M.R. , Albiges-Rizo C. , Bouvard D.
      J. Cell Biol.194:307-322(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    21. 21.
      "Solution structure and dynamics of linked cell attachment modules of mouse fibronectin containing the RGD and synergy regions: comparison with the human fibronectin crystal structure."
      Copie V. , Tomita Y. , Akiyama S.K. , Aota S. , Yamada K.M. , Venable R.M. , Pastor R.W. , Krueger S. , Torchia D.A.
      J. Mol. Biol.277:663-682(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1447-1630
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